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Alprazolam — Research & Analytical Reference Information

Synonyms

• 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
• Xanax (brand name)
• Niravam
• Alprazolamum
• Alprazolam Hydrochloride (salt form)

CAS Number

28981-97-7 (Alprazolam base)

Molecular Formula & Structure

• Formula: C₁₇H₁₃ClN₄
• Chemical Class: Triazolobenzodiazepine
• Structure Notes:
  Alprazolam features a benzodiazepine backbone fused with a triazole ring, contributing to its distinct pharmacological and analytical profile.
  (Visual structures can be referenced from chemical databases.)

Purity & Grade

• Purity: ≥98% research or analytical grade
• Available Forms: Powder, crystalline solid, or certified reference material
• Intended Use:
  Designed for laboratory studies, forensic investigations, analytical method development, and chemical characterization.

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Physical & Chemical Properties

• Appearance: White or off-white crystalline powder
• Melting Point: 228–229°C
• Solubility:
  • Sparingly soluble in water
  • Soluble in ethanol, methanol, DMSO
• Stability: Stable under recommended lab conditions; light-sensitive
• LogP: ~2.2 (moderate lipophilicity)

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Safety & Handling Information

Alprazolam is a controlled benzodiazepine and must be handled in compliance with strict laboratory safety standards.

Potential Hazards

• May cause skin, eye, and respiratory irritation
• Handle powder carefully to avoid aerosolization
• Avoid ingestion or accidental exposure

Required PPE

• Gloves
• Laboratory coat
• Protective eyewear
• Work under a fume hood when handling powders

First-Aid Measures

• Skin Contact: Rinse with water and soap
• Eye Contact: Rinse for 10–15 minutes with clean water
• Inhalation: Move to fresh air
• Ingestion: Seek prompt medical attention

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Research Uses & Applications

Alprazolam is widely utilized in scientific environments, including:

Key Research Areas

• Pharmacokinetic and metabolic profiling
• Benzodiazepine receptor studies
• Forensic toxicology and drug screening development
• LC-MS/MS and GC/MS analytical calibration
• Comparative studies of triazolobenzodiazepine analogs

This compound is not intended for human consumption or therapeutic use within a research-chemical context.

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Regulatory Information

Alprazolam is listed as a controlled substance in most regions.
Possession, handling, and research use may require:

• Licensed laboratory authorization
• Documented compliance with institutional protocols
• Secure storage as required by law

Researchers must confirm all local and international regulatory requirements before obtaining or working with this compound.

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Storage Guidelines

• Store in a cool, dry place
• Protect from direct sunlight
• Keep container tightly sealed
• Use desiccants to maintain stability when needed
• Store under secure, access-controlled conditions

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Extended Chemical Background

Alprazolam is part of the triazolobenzodiazepine family, characterized by:

• Fusion of a benzodiazepine ring with a triazole ring
• High affinity for GABA-A receptor sites in biochemical assays
• Distinctive metabolic pathways involving α-hydroxylation
• Relevance in reference studies for benzodiazepine detection and quantification

It serves as a foundational molecule in neurochemical, forensic, and analytical research involving CNS-active compounds.

 

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FAQ 

1. What is Alprazolam used for in research?

Alprazolam is used for toxicology studies, forensic analysis, analytical calibration, and receptor-binding research.

2. What purity is available for research-grade Alprazolam?

Research-grade Alprazolam is typically supplied at ≥98% purity for reliable laboratory performance.

3. Is Alprazolam intended for human or medical use on research sites?

No. In this context, Alprazolam is strictly for laboratory and analytical applications, not for human use.

4. How should Alprazolam be stored?

Store in a cool, dry place, inside a sealed container, protected from light and moisture.

5. Is Alprazolam regulated?

Yes. Alprazolam is controlled in many countries and may require special licensing to store or handle in a research environment.

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