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Amitriptyline — Research & Analytical Reference Information

Synonyms

• Amitriptyline Hydrochloride
• 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
• Elavil (brand name)
• Endep
• Tryptomer

CAS Number

50-48-6

Molecular Formula & Structure

• Formula: C₂₀H₂₃N
• Chemical Class: Tricyclic compound
• Structure Notes:
  Amitriptyline belongs to the tricyclic amine family, featuring a dibenzocycloheptene ring system connected to a dimethylaminopropyl side chain.
  (Researchers may refer to chemical databases for visual diagrams.)

Purity & Grade

• Purity: ≥ 98% (research/analytical grade)
• Form: Powder or crystalline solid, depending on supplier
• Intended Use:
  Laboratory studies, analytical calibration, pharmacological investigation, and research involving tricyclic antidepressant mechanisms.

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Physical & Chemical Properties

• Appearance: Off-white to white crystalline powder
• Melting Point: 195–198°C (for hydrochloride form)
• Solubility: Soluble in ethanol, methanol, chloroform; slightly soluble in water
• Stability: Stable under recommended storage; protect from excessive heat and moisture
• pKa: ~9.4 (basic tertiary amine group)

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Safety & Handling Information

Amitriptyline should be handled by trained laboratory professionals in accordance with safety protocols.

Potential Hazards

• May cause skin and eye irritation
• May cause respiratory irritation if dust is inhaled
• Avoid ingestion and prolonged exposure

Required PPE

• Gloves
• Safety glasses
• Laboratory coat
• Fume hood recommended when handling powders

First-Aid Measures

• Skin Contact: Rinse with water and soap
• Eye Contact: Flush eyes with water for 10–15 minutes
• Inhalation: Move to fresh air and monitor for symptoms
• Ingestion: Seek professional medical support

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Research Uses & Applications

Amitriptyline is widely used in laboratory and research environments for:

Primary Research Areas

• Pharmacological modelling of neurotransmitter reuptake inhibition
• Toxicology studies
• Analytical reference standard in chromatography and mass spectrometry
• Metabolic profiling in biological systems
• Tricyclic antidepressant mechanism studies

This compound is not intended for therapeutic or human consumption within a research chemical context.

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Regulatory Information

Amitriptyline may be regulated as a prescription-only medication in many countries.
Researchers must ensure compliance with relevant laws and institutional policies when acquiring or handling this chemical.

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Storage Guidelines

• Store in a cool, dry place
• Protect from direct sunlight
• Keep container sealed tightly
• Avoid exposure to humidity

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Extended Chemical Background

Amitriptyline is one of the earliest and most studied tricyclic compounds, often used as a reference material for understanding:

• Serotonin and norepinephrine reuptake inhibition
• Structure–activity relationship (SAR) within tricyclic analogs
• Metabolite formation, especially nortriptyline
• Interactions with central nervous system receptor pathways

Its well-established pharmacological profile makes it a key compound in neuropharmacological and forensic analytical research.

 

 

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FAQ 

1. What is Amitriptyline?

Amitriptyline is a tricyclic compound commonly used as a reference standard in laboratory and analytical research.

2. What is the purity level?

Research-grade Amitriptyline is typically available at ≥98% purity for analytical work.

3. How is Amitriptyline used in research?

It is used in pharmacology modelling, toxicology studies, and as an analytical standard in chromatographic methods.

4. Is Amitriptyline intended for human consumption?

No. In this context, Amitriptyline is intended strictly for research and laboratory analysis only.

5. How should researchers store Amitriptyline?

In a cool, dry, sealed container, away from direct sunlight and moisture.

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