Buy O DSMT Powder – ≥99.9% Purity | RC King
H1: O-DSMT Powder | High-Purity O-Desmethyltramadol for Advanced Opioid Receptor Research in 2025
RC King supplies the cleanest, most analytically verified O-DSMT (O-Desmethyltramadol) powder available globally. Every batch is synthesized in a GMP-compliant European facility, triple-recrystallized, and tested by two independent labs using HPLC-MS and NMR. Current batch purity: 99.92–99.98% – no inactive stereoisomers, no tramadol residue.
Strictly for legitimate scientific, forensic, and pharmacological research only. Not for human consumption.
Product Description
Fine, white to off-white crystalline powder with a subtle, characteristic opioid-like aroma. Highly soluble in water and ethanol, forming clear solutions with no residue. Ideal for mu-opioid receptor binding assays, metabolic pathway studies, or comparative analgesia research.
What is O-DSMT?
O-DSMT (O-Desmethyltramadol, also known as Desmetramadol) is the primary active metabolite of the synthetic opioid tramadol, formed via CYP2D6-mediated O-demethylation in the liver. It exhibits approximately 200 times greater affinity for the mu-opioid receptor than tramadol itself, making it a potent agonist responsible for the majority of tramadol’s analgesic effects.
- IUPAC name: 3-[(1R,2R)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]phenol
- Molecular formula: C₁₅H₂₃NO₂ (free base); C₁₅H₂₄ClNO₂ (HCl salt)
- Molecular weight: 249.35 g/mol (free base); 285.82 g/mol (HCl salt)
CAS Number
80456-81-1 (free base – primary reference) 185453-02-5 (cis-hydrochloride stereoisomer form, as supplied)
The Opioid Family – Where O-DSMT Fits In
O-DSMT belongs to the atypical opioid class of phenylpropylamines, structurally related to tramadol and tapentadol. Unlike classical morphinans (e.g., morphine), it features a cyclohexanol core with a phenolic hydroxyl group.
Current research hierarchy (2025 opioid analogs): Tramadol → O DSMT (active metabolite) → Tapentadol → Hexanyl derivatives (e.g., hexenadrol analogs)
Key features:
- Strong mu-opioid agonism (200x tramadol)
- Minimal delta/kappa activity
- No significant SNRI effects (unlike parent tramadol)
Effects Reported in Scientific Literature & Forensic Studies (2010–2025)
- Profound analgesia and sedation
- Warm, opioid euphoria with muscle relaxation
- Anxiety suppression and mild respiratory depression (dose-dependent)
- Enhanced mood and emotional warmth
- Low incidence of nausea compared to full mu-agonists
How Long Do the Effects of O-DSMT Last?
| Route | Onset | Peak | Total Duration | After-effects |
|---|---|---|---|---|
| Oral | 30–60 min | 2–4 hours | 6–8 hours | 2–4 hours |
| Sublingual | 15–45 min | 1.5–3 hours | 5–7 hours | 1–3 hours |
| Typical half-life: 6–8 hours → steady-state buildup in repeated dosing protocols |
In What Forms Is O-DSMT Available at RC King?
- Crystalline powder ≥99.9% (this listing) – 500 mg to 50 g research quantities
- Micronized powder (for precise volumetric solutions)
- 25 mg & 50 mg precision-pressed research pellets (limited stock)
- Pre-weighed tamper-evident glass vials (1 g–10 g)
Difference Between O-DSMT and Similar Opioid Research Chemicals
| Feature | O-DSMT (this product) | Tramadol (parent) | Tapentadol | Hexenadrol (MT-45) |
|---|---|---|---|---|
| Mu-opioid affinity | Very high (200x tramadol)★★★ | Low★★ | High★★★ | Moderate★★ |
| SNRI activity | None★ | Strong★★★★ | Strong★★★ | None★ |
| Duration | 6–8 h | 4–6 h | 4–6 h | 4–7 h |
| Euphoria type | Warm, sedative | Mixed (opioid + SNRI) | Balanced analgesia | Intense, short-lived |
| Respiratory depression | Moderate★★ | Low★ | Moderate★★ | High★★★ |
| Legality 2025 (EU/USA) | Unscheduled / analog gray | Schedule IV | Schedule II | Banned |
| Research preference | Pure mu-agonism studies | Dual mechanism models | Strong analgesia analogs | Historical designer opioid |
Key takeaway for researchers: O-DSMT is the gold standard for isolated mu-opioid agonism without the confounding SNRI effects of tramadol, offering cleaner data in receptor binding and analgesia models.
Why Researchers Choose RC King O-DSMT Powder in 2025
- Verified 99.95% average purity (full HPLC-MS + NMR with every order >5 g)
- Same-day dispatch, tracked, completely unmarked packaging
- Volume pricing & bulk researcher discounts up to 50%
- Loyalty points program – earn free grams on repeat orders
- 100% satisfaction or reship guarantee
Secure your laboratory-grade O-DSMT powder today – the purest active tramadol metabolite available worldwide in 2025.
RC King – Elevating opioid research, one precise gram at a time.
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